PubMed Publications

• Efficacy of andexanet alfa in non-surgical patients with spontaneous DOAC related intracerebral hemorrhage Abstract: CONCLUSION: In our study, patients who received Andexxa therapy and non-surgical management of spontaneous ICH showed no difference in ICH expansion within 24 h but had increased cost of care. Further studies should examine whether Andexxa is of clinical value for patients with spontaneous ICH.
• Novel association of the Rotterdam computed tomography score with decompressive craniectomy in acute traumatic subdural hematoma Abstract: CONCLUSION: A RCT score of greater than or equal to 3, a younger age, and lower GCS were associated with increased odds of undergoing DC compared to CO for traumatic aSDHs. RCT scores are associated with DC versus CO in patients with aSDH.
• Meta-analysis of early versus late fixation of traumatic unstable thoracolumbar spine fractures in patients with or without spinal cord injury Abstract: CONCLUSION: Early fixation of traumatic thoracolumbar fractures is associated with decreased HLOS, ICULOS, complication rates, and ventilator dependency. Further prospective trials are required to confirm these findings and refine the role of SCI status in clinical decision-making for thoracolumbar fixation.
• Predictors of withdrawal of life-sustaining therapies in older adults with TBI and a modified frailty index score Abstract: CONCLUSIONS: This study demonstrates that patients ≥ 65 years old with poor initial GCS, cerebral edema, craniotomy/craniectomy, and DNAR were all independently associated with WLST. Pre-injury frailty was not associated with WLST. Further studies are needed to evaluate the prognostic value of frailty indices in the management of patients with TBI.
• Social determinants and follow-up care after emergency department discharge for traumatic intracranial hemorrhage Abstract: CONCLUSION: We observed racial and SES differences in follow-up care from the ED for patients with TBI. Individualized discharge planning and formulation of care pathways that account for the mental health and social needs of all patients may improve long-term outcomes. Further understanding of health disparities present in ED TBI care is needed.
• Welfare Implications of Low-Dose Atipamezole Reversal of Tiletamine/Zolazepam/Xylazine Anaesthesia in Pigs Abstract: Anaesthesia is sometimes required for the effective restraint of laboratory pigs for sample collection. Yet, anaesthesia can initiate a range of physiological disruptions that can increase variability in study data and lead to poorer animal welfare. Judicious use of anaesthesia can mitigate experimental, human safety, and animal welfare concerns, but it does not eliminate the potential for adverse effects. The use of reversal agents can shorten recovery time and reduce the physiological impacts...
• Experimental infection of ringtail possums (Pseudocheirus peregrinus) with Mycobacterium ulcerans, the agent of Buruli ulcer Abstract: Buruli ulcer (BU) is a necrotizing disease of skin and soft tissue caused by the bacterium Mycobacterium ulcerans (MU). In Australia, where the disease is emerging in new geographic areas and human case numbers are increasing, native possum species act as reservoir hosts. To better understand the life history of MU in one of its natural hosts, we conducted intra-dermal challenge of six wild caught, MU-naïve common ringtail possums (Pseudocheirus peregrinus). All six animals developed BU disease...
• Novel application of latent class analysis to outcome assessment in traumatic brain injury with multiple injury subtypes or poly-TBI Abstract: CONCLUSIONS: Distinct poly-TBI classes were associated with increased in-hospital mortality and WLST. Further research with larger datasets will allow for more comprehensive poly-TBI class definitions and outcomes analysis.
• An electrophysiological correlate of sleep in a shark Abstract: Sleep is a prominent physiological state observed across the animal kingdom. Yet, for some animals, our ability to identify sleep can be masked by behaviors otherwise associated with being awake, such as for some sharks that must swim continuously to push oxygenated seawater over their gills to breathe. We know that sleep in buccal pumping sharks with clear rest/activity cycles, such as draughtsboard sharks (Cephaloscyllium isabellum, Bonnaterre, 1788), manifests as a behavioral shutdown,...
• Neighborhood Deprivation is Associated With Hospital Length of Stay, Discharge Disposition, and Readmission Rates for Patients Who Survive Hospitalization With Traumatic Brain Injury Abstract: CONCLUSION: After adjusting for confounders, including comorbidities, TBI mechanism/severity, and age, higher ADI was independently predictive of longer hospital LOS, increased risk of 90-day readmission, and nonhome discharge. These results may help establish targeted interventions to identify at-risk patients after TBI.
• Impact of preoperative mental health diagnosis on postoperative opioid use patterns in spine fusion surgery: A systematic literature review Abstract: Opioids are frequently prescribed for patients undergoing procedures such as spinal fusion surgery for the management of chronic back pain. However, the association between a preoperative mental health illness, such as depression or anxiety, and opioid use patterns after spinal fusion surgery remain unclear. Therefore, we performed a systematic literature review in accordance with PRISMA guidelines to identify articles from the PubMed Database that analyzed the relationship between preoperative...
• Incidence of Sacroiliac Joint Pain Following Lumbar Fractures: A Retrospective-Cohort Study Abstract: CONCLUSIONS: Our findings suggest that lumbar fractures are a risk factor for developing SIJ pain. Moreover, the incidence of SIJ pain is greater following an L5 fracture than an L1 fracture. Further investigation is warranted to determine how the type and treatment of lumbar fractures affects the incidence of SIJ pain.
• Outcomes After the Surgical Evacuation of Traumatic Acute Subdural Hematomas: The tASDH Risk Score Abstract: CONCLUSIONS: Octogenarians with an RCS of 4-6 and an admission GCS <13 have a high risk of mortality following tASDH evacuation. Knowledge of which patients are unlikely to survive ASDH evacuation may help guide neurosurgeons in prognostication and goals of care discussions.
• Diffuse Axonal Injury Pattern Predicts Timing of In-Hospital Neurologic Recovery: A Retrospective Case Series Abstract: CONCLUSIONS: Patients with grade 1 DAI demonstrated the fastest short-term neurologic recovery, although final discharge neurologic examination was comparable across DAI grades. DAI classification can provide useful short-term prognostic information regarding in-hospital neurologic improvement.
• Canal narrowing in adult patients with cervical spinal cord injury without computed tomography evidence of trauma Abstract: CONCLUSION: Degenerative changes or CCS may narrow the minimum cervical SCD beyond the threshold at which low-energy trauma results in C-SCI. Adult patients with cervical spinal stenosis, whether congenital and/or degenerative, and neurologic findings referable to the cervical spine should be assessed for C-SCI.