PubMed Publications

• Timing of neurorehabilitation and subsequent Alzheimer's disease risk in patients with moderate to severe traumatic brain injury: A nationwide retrospective cohort study in the United States Abstract: BackgroundTraumatic brain injury (TBI) is associated with an increased risk of Alzheimer's disease (AD). It is unknown if prompt neuro-rehabilitative treatment following moderate or severe TBI mitigates this risk compared with delayed treatment.ObjectiveTo determine whether immediate neuro-rehabilitative treatment following moderate or severe TBI reduces the risk of AD and related cognitive outcomes compared with delayed treatment.MethodsWe conducted a retrospective cohort using the TriNetX...
• Associations of selective serotonin reuptake inhibitors and long COVID risk in patients with depression: a retrospective cohort study Abstract: CONCLUSIONS: In adult patients with depression, SSRIs compared with non-SSRI antidepressants were associated with a lower risk of long COVID. These results offer preliminary evidence that SSRIs may help prevent long COVID in high‑risk populations and warrant further preclinical and clinical investigation.
• Low-Dose Aspirin: The Safest Prophylactic Approach for Venous Thromboembolism Prevention Following Total Hip Arthroplasty Across All Risk Profiles Abstract: CONCLUSIONS: Low-dose aspirin was associated with significantly lower rates of thromboembolic, bleeding, and mortality outcomes in both high- and low-risk THA patients. These findings support the ICM recommendation of aspirin as a safe, effective, and broadly applicable thromboprophylaxis strategy following THA.
• Comparison of Long-Term Revision Rates and Health Care Utilization Between Standalone Balloon Sinus Dilation and Endoscopic Sinus Surgery in Chronic Rhinosinusitis Patients Without Nasal Polyps: Is the Balloon Value Proposition Overinflated? Abstract: BackgroundPrevious research has reported inconsistent results when evaluating long-term revision rates of patients undergoing balloon sinus dilation (BSD) compared to primary endoscopic sinus surgery (ESS).ObjectiveWe aimed to compare outcomes and long-term rates of revision surgery in patients with chronic rhinosinusitis without nasal polyps (CRSsP) who underwent primary standalone BSD versus primary ESS. We also wanted to better understand the post-procedure utilization of major healthcare...
• Metformin and the Development of Age-Related Macular Degeneration Abstract: CONCLUSION AND RELEVANCE: This study suggests that, overall, metformin is not associated with significant development or progression of AMD. Further studies and prospective analyses are necessary to evaluate whether dosage and longevity of metformin use are associated with AMD development or progression.
• Adverse Pregnancy Outcomes in Patients with Congenital Uterine Anomalies: Evaluation of a Population Dataset Abstract: This study aimed to characterize the risk of adverse pregnancy outcomes among patients with congenital uterine anomalies (CUA) using electronic health record data.Retrospective cohort study utilizing the TriNetX analytics research network, including female patients aged 10 to 55 with a documented singleton and intrauterine pregnancy.A total of 561,440 patients met inclusion criteria, of whom 3,381 (0.6%) had one or more International Classification of Diseases (ICD) encounter diagnosis codes for...
• Glucagon-Like Peptide-1 Receptor Agonists and Risk of Uveitis Abstract: CONCLUSIONS AND RELEVANCE: This cohort study found that GLP-1RA prescriptions were associated with a lower risk of uveitis compared with controls. These findings suggest potential anti-inflammatory benefits beyond glycemic control, warranting further investigation into their role in ocular inflammatory diseases.
• Sodium Glucose Co-Transporter-2 inhibitors in patients with systemic sclerosis with or without heart failure Abstract: CONCLUSION: In this real-world analysis, SGLT2 inhibitors were associated with reduced mortality, stroke, and hospitalization in patients with systemic sclerosis, supporting their potential therapeutic role in this population.
• Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes Abstract: CONCLUSIONS AND RELEVANCE: In this study of patients with type 2 diabetes who had no prior eye disorders, patients prescribed semaglutide or tirzepatide had an increased risk of NAION and other optic nerve disorders, although the overall risk was low. These findings highlight the need for close monitoring of these conditions.
• Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection Abstract: Pediatric SARS-CoV-2 infection results in clinical presentations ranging from asymptomatic/mild infection to severe pulmonary COVID-19, to Multisystem Inflammatory Syndrome in Children (MIS-C), characterized by hyperinflammation and multi-organ involvement. While various aspects of antibody responses to pediatric SARS-CoV-2 infection manifestations have been reported, parallel studies of antibody responses to viral and self-antigens are understudied. We tested whether clinical presentations of...
• Early-Onset Colorectal Cancer: A Review of Current Insights and a Call for Action Abstract: While the incidence of colorectal cancer (CRC) in patients above 50 years old has been decreasing over the last several decades, the incidence of CRC among younger patients has been increasing. Early-onset CRC (EO-CRC) is known to exhibit distinct characteristics including specific genetic mutations and modifiable risk factors, which warrants tailored screening and management approaches. This review synthesizes current insights on EO-CRC's epidemiological, genetic, molecular, and clinical...
• Trends and Disparities in the Incidence and Prevalence of Inherited Retinal Diseases in the United States Abstract: CONCLUSIONS: Our findings suggest an increased ascertainment of the incidence and prevalence of IRDs in the US in the setting of diagnostic and treatment advances. We also reveal previously unreported disparities in the prevalence of these conditions by race, highlighting a potential gap in our understanding of genetic disease in diverse populations.
• Associations between obstructive sleep apnoea and the development and severity of retinal vein occlusion Abstract: CONCLUSIONS: OSA is associated with an increased risk of RVO among various populations, especially among Hispanic/Latino. Among patients with preexisting RVO, OSA is associated with indicators of more severe RVO.
• Prevalence of obstructive sleep apnea and related oropharyngeal symptoms in pediatric Ehlers Danlos patients Abstract: CONCLUSION: Children with EDS are at a higher risk of developing OSA and other oropharyngeal symptoms like dysphagia and dysphonia. These patients are also more likely to undergo adenotonsillar surgeries as a first-line approach to correcting obstructive sleep apnea. Otolaryngologists and speech language pathologists can play a major beneficial role in working with pediatric EDS patients in the management and treatment of oropharyngeal symptoms.
• Characterizing Long COVID Symptoms During Early Childhood Abstract: CONCLUSIONS AND RELEVANCE: This cohort study identified symptom patterns and derived research indices that were distinct between the 2 age groups and differed from those previously identified in older ages, demonstrating the need to characterize LC separately across age ranges.